In Nature Communications, a research team presents a structure-based approach to psychedelic analogs that activate the 5-HT₂A receptor while sparing the 5-HT₂B receptor linked to heart valve damage.
Researchers have detected the synthetic psychedelic 4-HO-MET in four commercially sold tablets and one unlabeled powder.
A narrative review proposes that psychedelics could contribute to healthspan, while stressing there is no evidence they extend lifespan or slow aging.
A narrative review in Molecular Psychiatry examines how estradiol, progesterone, and hormonal changes could shape psychedelic effects and tolerability.
A literature review by Kevin Feeney and Tristan Kallweit finds no sufficient evidence that Amanita muscaria is commonly or reliably lethally used in suicide.
An in-silico study in Molecules suggests numerous psychedelic substances and their analogues could cross the human placenta relatively easily.
A systematic review finds consistent pain-inhibiting effects of kratom in preclinical models, while clinical efficacy in humans remains unproven.
A systematic review finds the evidence on mescaline for psychiatric conditions too limited and inconsistent to judge either benefit or safety.
A review of 104 peer-reviewed articles examines the mental, physical, and social effects of psychedelic use outside clinical settings.
Nine computational models were used to estimate the health risks of six PCP analogues, pointing to organ and cardiac risks but no genotoxicity.
A review examines how metabolomic methods can improve the forensic analysis of synthetic cathinones and support toxicology and public health.
A narrative review finds fly agaric increasingly marketed like a new psychoactive substance, with known risks and no treatment guidelines.
Researchers in Japan report the first detection of two new LSD analogues, 1Bz-LSD in tablets and 1-TMSBz-LSD on paper blotters.
A review finds machine learning is helping analytical toxicology identify new psychoactive substances and predict structures and retention times.
Researchers map 56 metabolites of the new psychoactive substance 25E-NBOH across three model systems and propose three biomarkers for detection.
A review of cannabis policy from 2000 to 2025 finds that decriminalization and tightly regulated legalization do not automatically raise consumption.
A University of Winchester survey collects anonymous reports from adults who have used the fly agaric mushroom in the past five years.
Interviews with 19 people who have lived through both psychosis and psychedelics suggest the two states overlap far less than long assumed.
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