An analysis of two British birth cohorts finds that people with past psilocybin or LSD use more often hold positive attitudes toward nature conservation and more often eat a vegetarian diet.
An anonymous online survey at the University of Exeter is examining whether and how women have used psychedelic substances as a coping strategy in perimenopause and postmenopause.
Researchers have reconstructed the biosynthesis of DMT, psilocybin, psilocin, bufotenin, and 5-MeO-DMT in plants, creating a platform for producing and modifying these tryptamines.
In Nature Communications, a research team presents a structure-based approach to psychedelic analogs that activate the 5-HT₂A receptor while sparing the 5-HT₂B receptor linked to heart valve damage.
A cultural studies chapter traces how psychedelics in surf culture moved from the countercultural soul surfing of the 1960s to a subject framed in medical and therapeutic terms.
A nationally representative RAND survey estimates that around 9.5 million adults in the United States microdosed psilocybin, MDMA or LSD at least once in 2025.
An interdisciplinary paper asks whether psychedelics, through their effects on neuroplasticity and social behavior, could contribute to future processes of human adaptation.
In several mouse models, two doses of psilocybin given before chemotherapy prevented chemotherapy-induced peripheral neuropathy from developing.
A study in ACS Chemical Neuroscience suggests that blocking the serotonin transporter can dampen the psychedelic effects of certain tryptamines.
A study in Molecular Psychiatry is the first to systematically examine the acute effects of 2C-B on the human brain, alongside psilocybin.
Emanuel Jas asks whether psychedelic experiences helped humans develop the idea of objective moral truths, combining anthropology and moral philosophy.
A narrative review proposes that psychedelics could contribute to healthspan, while stressing there is no evidence they extend lifespan or slow aging.
A narrative review in Molecular Psychiatry examines how estradiol, progesterone, and hormonal changes could shape psychedelic effects and tolerability.
A Nature study finds psilocybin does not simply disorder brain activity but couples network dynamics more closely to the situation being experienced.
A literature review by Kevin Feeney and Tristan Kallweit finds no sufficient evidence that Amanita muscaria is commonly or reliably lethally used in suicide.
A critical review examines the evidence on psilocybin, LSD, ayahuasca, DMT, and mescaline in chronic pain and finds it promising but preliminary.
A review by pharmacologist Daniel Hoyer surveys psychedelics, entactogens, and psychoplastogens as fast-acting approaches in depression and related disorders.
A paper sets out how spiritual and religious themes can be systematically integrated into training for psychedelic-assisted psychotherapy.
A meta-analysis finds a significant association between psychedelic experiences and reduced death anxiety, with mystical experiences playing a role.
Psilocybin-containing mushrooms interest both ecologists and pharmacologists: why the fungi produce psilocybin at all, and what it may offer medicine.
A review by Gül Dölen and Makenzie L. Wilkinson proposes that psychedelics temporarily increase the adult brain's capacity for learning and adaptation.
An in-silico study in Molecules suggests numerous psychedelic substances and their analogues could cross the human placenta relatively easily.
A study in Psychedelics finds no reliable historical evidence for an ancient Comcáac tradition of using Sonoran Desert toad secretion and traces how the narrative arose.
Targeted activation of the 5-HT2A receptor strengthened the antitumor immune response and slowed colorectal cancer growth in preclinical models.
A review examines the opioid system in altered states of consciousness and presents salvinorin A as a clear case of a non-serotonergic mechanism.
A commentary asks how well psychedelic treatment models developed in Western countries transfer to other cultural contexts, using Chinese palliative care.
An international team proposes replacing the term psychedelic renaissance with the concept of a confluence, centering indigenous knowledge systems.
An fMRI study in awake rats characterizes how mescaline changes cerebellar activity, resting-state connectivity and the processing of sensory information.
A new review identifies 165 ongoing clinical trials with classic psychedelics, most of them early-phase, US-based, and focused on depression.
An intern at the Psychedelia Foundation built the Consciousness Library, a free and growing directory of research on psychedelics and consciousness.
An updated systematic review of 48 studies finds the most consistent signals in higher openness and lower neuroticism after classic psychedelics.
A systematic review finds the evidence on mescaline for psychiatric conditions too limited and inconsistent to judge either benefit or safety.
A Psychedelia Foundation case study documents sustained abstinence in severe ketamine use disorder after an ibogaine-assisted treatment.
A review of 104 peer-reviewed articles examines the mental, physical, and social effects of psychedelic use outside clinical settings.
A review maps psychedelic research along three axes, consciousness, cultural context, and clinical application, and calls for an integrated framework.
Eleven fMRI datasets and five psychedelics pooled into one analysis reveal a shared pattern of stronger cross-network communication in the brain.
A systematic review of 16 human studies finds short-term gains in working memory, flexibility and empathy, on a still thin evidence base.
A new review gathers the experience of leading British research groups into practical guidance for planning studies with psychedelic substances.
A new paper argues that standardized full-spectrum Psilocybe extracts should be studied alongside isolated psilocybin in therapy research.
Interviews with 19 people who have lived through both psychosis and psychedelics suggest the two states overlap far less than long assumed.
A review of 49 electrophysiological studies finds that psychedelics modulate neuronal activity in more varied ways than standard models suggest.
A scoping review of 103 naturalistic studies finds that setting, the context of psychedelic use, is often documented poorly or not at all.
A review of preclinical animal studies asks what classic psychedelics could contribute to research on autism spectrum disorders.
In helpless mice, DMT acted as quickly as S-ketamine against depressive behavior, and its anxiolytic effects lasted considerably longer.
In a small retrospective study, nearly half of the patients with treatment-resistant depression saw no clear improvement in anhedonia under ketamine.
A new review compiles every known academic and patented synthesis route for bufotenine and 5-MeO-DMT and compares them for efficiency.
A single 20-minute exposure to psilocybin lowered activity and aggressive swimming bursts in the mangrove rivulus, a fish used to model territorial behavior.
An exploratory study with 28 psychedelic-naive adults found changes in brain activity, imaging measures, and subjective experience up to a month later.
The first TRYP EXPO turns Funkhaus Berlin into a meeting point for psychedelic culture and research from May 15 to 17, with Markus Berger speaking on Sunday.
A new review questions whether increased brain entropy can already serve as a reliable biomarker of the effects of serotonergic psychedelics.
Two new reviews assess the available human research on mescaline and 5-MeO-DMT and find the evidence base still too thin for clinical recommendations.
A year of building, encounters, and new connections. Thank you for being here. Here is our annual report for 2025. 2025 was a year of building for Psychedelia Foundation, shaped by exchange, encounters, and new...
July 24–31, 2025 – Negril, JamaicaIn cooperation with the University of Ottawa, the University of Washington, CISN ICBH and the Psychedelia-Foundation The Psychedelia Foundation is part of a multi-institutional...
We founded the non-profit Psychedelia-Foundation out of the conviction that the responsible and respectful use of psychedelic substances - and a deeper understanding of their effects on consciousness and perception -...
The Psychedelia Foundation is proud to collaborate as a community partner with a number of leading organizations and initiatives. These partnerships are key to our mission of promoting and advancing the exploration of...
No articles found
Try a different spelling or clear the filters.
Stay connected with a community that fosters a responsible and forward-thinking dialogue on psychedelic experience – and receive news about projects, events, and publications.
By subscribing, you agree to our Privacy Policy.