Psychedelics as possible factors in future human adaptation
An interdisciplinary paper asks whether psychedelics, through their effects on neuroplasticity and social behavior, could contribute to future processes of human adaptation.
Topic - neuroscience
Psilocybin prevents chemotherapy-related nerve damage in preclinical study
In several mouse models, two doses of psilocybin given before chemotherapy prevented chemotherapy-induced peripheral neuropathy from developing.
Mechanism discovered for weakened psychedelic effects
A study in ACS Chemical Neuroscience suggests that blocking the serotonin transporter can dampen the psychedelic effects of certain tryptamines.
2C-B changes the brain’s functional organization much like psilocybin, but not identically
A study in Molecular Psychiatry is the first to systematically examine the acute effects of 2C-B on the human brain, alongside psilocybin.
Psilocybin aligns brain activity more closely with context
A Nature study finds psilocybin does not simply disorder brain activity but couples network dynamics more closely to the situation being experienced.
Psychedelics change cognitive functions unevenly
A systematic review of 32 placebo-controlled studies finds LSD, DMT, and psilocybin affect cognition differently depending on function, dose, and timing.
Psychedelics could open the brain to new learning
A review by Gül Dölen and Makenzie L. Wilkinson proposes that psychedelics temporarily increase the adult brain's capacity for learning and adaptation.
Rapamycin blocks addiction-related behavioral adaptations to MDPV in mice
In mice, the mTOR inhibitor rapamycin prevented both the development and the later expression of locomotor sensitization caused by the cathinone MDPV.
Scoping review: music shapes psychedelic experiences, but the evidence remains limited
A scoping review of 19 quantitative studies finds that music shapes the acute psychedelic experience, while methods and sample sizes limit the evidence.
Mescaline alters cerebellar function and global brain connectivity: new fMRI study in rats points to mechanisms behind psychedelic changes in perception
An fMRI study in awake rats characterizes how mescaline changes cerebellar activity, resting-state connectivity and the processing of sensory information.
Lasting effects of LSD on motor learning and neural signals
A randomized crossover trial in 45 healthy adults links a single 100 microgram dose of LSD to changes in learning and neurophysiology days later.
Case study compares nondual meditation and 5-MeO-DMT for the first time
A controlled single-case study compares nondual meditation with two doses of 5-MeO-DMT in an expert meditator, using high-density EEG.
Mega-analysis: how psychedelic substances affect the brain
Eleven fMRI datasets and five psychedelics pooled into one analysis reveal a shared pattern of stronger cross-network communication in the brain.
Ayahuasca shows positive effects on cognition and social perception, but the evidence remains limited
A systematic review of 16 human studies finds short-term gains in working memory, flexibility and empathy, on a still thin evidence base.
A glimmer of hope or a single case? Mushroom compound temporarily returns speech and daily life to an Alzheimer’s patient
A case report describes a woman with advanced Alzheimer's regaining speech and mobility for weeks after a single high dose of psilocybin mushrooms.
Psychedelics change neuronal signal processing in more complex ways than assumed
A review of 49 electrophysiological studies finds that psychedelics modulate neuronal activity in more varied ways than standard models suggest.
New review: psychedelics in autism spectrum disorders
A review of preclinical animal studies asks what classic psychedelics could contribute to research on autism spectrum disorders.
Study: psilocybin reduces aggressive behavior in mangrove rivulus fish
A single 20-minute exposure to psilocybin lowered activity and aggressive swimming bursts in the mangrove rivulus, a fish used to model territorial behavior.
Study: a single psilocybin experience comes with measurable changes in the brain
An exploratory study with 28 psychedelic-naive adults found changes in brain activity, imaging measures, and subjective experience up to a month later.
Brain entropy as a biomarker of the psychedelic state?
A new review questions whether increased brain entropy can already serve as a reliable biomarker of the effects of serotonergic psychedelics.
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