Psychedelic tryptamine 4-HO-MET detected in commercial tablets

Eine umgekippte braune Tablettendose auf einem Holztisch, aus der bunte Tabletten und Kapseln herausgerollt sind.

Translated from our German original by AI. The German text was researched, written, and edited by the Psychedelia Foundation team and remains the authoritative version.

A recent analysis has detected the synthetic psychedelic 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) in commercially available tablets. The substance is structurally and pharmacologically related to psilocin.

For the study, researchers analyzed four tablets marketed under the brand name “Party Duck”, two pink “Mellymell” and two orange “Juiceman”, along with an unlabeled powder. Using liquid chromatography mass spectrometry (LC/MS), gas chromatography mass spectrometry (GC/MS) and nuclear magnetic resonance spectroscopy (NMR), the researchers identified 4-HO-MET unambiguously in every material they tested.

The four tablets contained between 1.23 and 1.66 milligrams of 4-HO-MET per unit, an average of 1.45 milligrams. Relative to the weight of the tablets, this corresponded to an average of 2.82 milligrams per gram. The authors also report that 4-HO-MET was the only psychoactive component in the products they examined.

The analysis therefore shows that the synthetic tryptamine is present in commercially marketed products on the unregulated market. According to the authors, the finding underlines the importance of analytical methods for monitoring new tryptamine derivatives and for examining products sold as legal alternatives to controlled substances.

Source

Barovic A, Pittiglio MK, Barrett JM, Aretz CDJ, Tesfatsion TT, Ramirez GA, Cruces W. (2026), Presence of 4‑Hydroxy‑N‑methyl‑N‑ethyltryptamine in Commercially Available Products, ACS Omega 11(2): 3448-3454.

Read the study, opens in a new tab pmc.ncbi.nlm.nih.gov

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