Translated from our German original by AI. The German text was researched, written, and edited by the Psychedelia Foundation team and remains the authoritative version.
For some time now a trend has been visible worldwide, with ever new analogues of lysergic acid diethylamide (LSD) appearing on the market. A recent scientific investigation from Japan examines this development on the basis of specific product findings. Even after strict regulation of derivatives already known, manufacturers operating in the legal grey zone apparently keep managing to put new compounds with modified chemical structures into circulation in order to circumvent existing laws.
In the present study, researchers succeeded in identifying two LSD analogues not previously documented in this form in Japan. The substances were detected in products that were freely available through Japanese online channels and sold there either as tablets or on conventional paper blotters. To identify the unknown compounds precisely and to elucidate their structures, the team drew on a broad range of state-of-the-art analytical methods. Exact determination was achieved by combining gas chromatography mass spectrometry, liquid chromatography with photodiode array detection and mass spectrometry, and liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry. The structural elucidation was completed and finally confirmed by nuclear magnetic resonance spectroscopy (NMR) measurements.
These analyzes made it possible to identify both chemical compounds unambiguously. In the tablets examined, the scientists detected the substance 4-benzoyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide, referred to in short as 1Bz-LSD. In the paper products, by contrast, they detected the analogue N,N-diethyl-7-methyl-4-(4-(trimethylsilyl)benzoyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide, better known by the abbreviation 1-TMSBz-LSD.
The publication is the first report of these two specific LSD analogues being detected in tablet and blotter form in Japan. The results underline how dynamic the market for new psychoactive substances is, and that the synthesis of new derivatives often happens faster than their legal classification on the ground.
